Activation of phospholipases A2 and D of a human neuroblastoma cell line (LA-N-2) by N-dodecyl-L-lysine amide (compound 24), a putative G protein activator: characteristics of inhibition by (-)-nicotine.
Identifieur interne : 002F83 ( Main/Exploration ); précédent : 002F82; suivant : 002F84Activation of phospholipases A2 and D of a human neuroblastoma cell line (LA-N-2) by N-dodecyl-L-lysine amide (compound 24), a putative G protein activator: characteristics of inhibition by (-)-nicotine.
Auteurs : Byron M. Garnham [Canada] ; Shirley Fitzpatrick-Wong ; Walter Schunack ; Bernd Nürnberg ; Giuseppe Sorrentino ; Fiona E. Parkinson ; Julian N. Kanfer ; Daniel S. SitarSource :
- Neurochemical research [ 0364-3190 ] ; 2002.
English descriptors
- KwdEn :
- Base Sequence, DNA Primers, Enzyme Activation, Enzyme Inhibitors (pharmacology), GTP-Binding Proteins (metabolism), Humans, Lysine (analogs & derivatives), Lysine (pharmacology), Neuroblastoma (enzymology), Neuroblastoma (pathology), Nicotine (pharmacology), Phospholipase D (antagonists & inhibitors), Phospholipase D (metabolism), Phospholipases A (antagonists & inhibitors), Phospholipases A (metabolism), Phospholipases A2, Receptors, Nicotinic (genetics), Receptors, Nicotinic (metabolism), Tumor Cells, Cultured.
- MESH :
- chemical , analogs & derivatives : Lysine.
- chemical , antagonists & inhibitors : Phospholipase D, Phospholipases A.
- chemical , genetics : Receptors, Nicotinic.
- chemical , metabolism : GTP-Binding Proteins, Phospholipase D, Phospholipases A, Receptors, Nicotinic.
- chemical , pharmacology : Enzyme Inhibitors, Lysine, Nicotine.
- chemical : DNA Primers, Phospholipases A2.
- enzymology : Neuroblastoma.
- pathology : Neuroblastoma.
- Base Sequence, Enzyme Activation, Humans, Tumor Cells, Cultured.
Abstract
Compound 24, an alkyl-substituted amino acid amide, previously found to activate pertussis toxin-sensitive G proteins in cell membranes and membrane protein fractions, was used as a tool to determine the mechanism/location of nicotine inhibition of amyloid beta peptide-stimulated phospholipase A2 and D activities in a human neuroblastoma cell line, LA-N-2, in vitro. In contrast to our previous findings with amyloid beta peptide, these phospholipase activations by compound 24 were not inhibited by (-)-nicotine, cholera toxin or tetanus toxin pretreatment. The contrasting activation of these phospholipases by amyloid beta peptide and compound 24 are discussed.
PubMed: 12515313
Affiliations:
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Le document en format XML
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Garnham</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacology and Therapeutics, University of Manitoba, A220-770 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0W3.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Pharmacology and Therapeutics, University of Manitoba, A220-770 Bannatyne Avenue, Winnipeg, MB</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Fitzpatrick Wong, Shirley" sort="Fitzpatrick Wong, Shirley" uniqKey="Fitzpatrick Wong S" first="Shirley" last="Fitzpatrick-Wong">Shirley Fitzpatrick-Wong</name></author><author><name sortKey="Schunack, Walter" sort="Schunack, Walter" uniqKey="Schunack W" first="Walter" last="Schunack">Walter Schunack</name></author><author><name sortKey="Nurnberg, Bernd" sort="Nurnberg, Bernd" uniqKey="Nurnberg B" first="Bernd" last="Nürnberg">Bernd Nürnberg</name></author><author><name sortKey="Sorrentino, Giuseppe" sort="Sorrentino, Giuseppe" uniqKey="Sorrentino G" first="Giuseppe" last="Sorrentino">Giuseppe Sorrentino</name></author><author><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name></author><author><name sortKey="Kanfer, Julian N" sort="Kanfer, Julian N" uniqKey="Kanfer J" first="Julian N" last="Kanfer">Julian N. Kanfer</name></author><author><name sortKey="Sitar, Daniel S" sort="Sitar, Daniel S" uniqKey="Sitar D" first="Daniel S" last="Sitar">Daniel S. 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In contrast to our previous findings with amyloid beta peptide, these phospholipase activations by compound 24 were not inhibited by (-)-nicotine, cholera toxin or tetanus toxin pretreatment. The contrasting activation of these phospholipases by amyloid beta peptide and compound 24 are discussed.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><noCountry><name sortKey="Fitzpatrick Wong, Shirley" sort="Fitzpatrick Wong, Shirley" uniqKey="Fitzpatrick Wong S" first="Shirley" last="Fitzpatrick-Wong">Shirley Fitzpatrick-Wong</name><name sortKey="Kanfer, Julian N" sort="Kanfer, Julian N" uniqKey="Kanfer J" first="Julian N" last="Kanfer">Julian N. Kanfer</name><name sortKey="Nurnberg, Bernd" sort="Nurnberg, Bernd" uniqKey="Nurnberg B" first="Bernd" last="Nürnberg">Bernd Nürnberg</name><name sortKey="Parkinson, Fiona E" sort="Parkinson, Fiona E" uniqKey="Parkinson F" first="Fiona E" last="Parkinson">Fiona E. Parkinson</name><name sortKey="Schunack, Walter" sort="Schunack, Walter" uniqKey="Schunack W" first="Walter" last="Schunack">Walter Schunack</name><name sortKey="Sitar, Daniel S" sort="Sitar, Daniel S" uniqKey="Sitar D" first="Daniel S" last="Sitar">Daniel S. Sitar</name><name sortKey="Sorrentino, Giuseppe" sort="Sorrentino, Giuseppe" uniqKey="Sorrentino G" first="Giuseppe" last="Sorrentino">Giuseppe Sorrentino</name></noCountry><country name="Canada"><region name="Manitoba"><name sortKey="Garnham, Byron M" sort="Garnham, Byron M" uniqKey="Garnham B" first="Byron M" last="Garnham">Byron M. Garnham</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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